These duplications most commonly occur in one of two forms. These include an extra isodicentric 15 chromosome, abbreviated idic(15), or an interstitial duplication 15, abbreviated int dup(15). When the duplicated material comes from the maternal chromosome, developmental problems are often the result. In most cases of chromosome 15q duplication syndrome, the chromosome duplication is not inherited, but occurred as a random event during the formation of reproductive cells.
For the past two years, researchers at Texas A&M University have worked to create a group of mice with increased levels of UBE3A, a key gene in dup15q syndrome. Now the mice are ready for the next step - behavior studies at the University of California Davis. It's a long, expensive journey. Please help us get our mice to California, by making a donation today!