Conference intended for scientists, researchers and professionals interested in Duplication 15q Syndrome

When: September 19-20, 2013

Where: MIND Institute
University of California Davis

We've secured a special room rate for meeting participants at the Marriott Courtyard Sacramento
Midtown. For reservations, click here. The group code for the special rate is dupdupa. The hotel 
(4222 Y Street, Sacramento) is a short walk from the MIND Institute (2825 50th Street, Sacramento).

There is no fee to register for the meeting. Please fill out the online registration form below. This
meeting was financed in part through the generous support of our sponsors. We gratefully
acknowledge the support of:

Tentative Agenda:

Thursday, September 19th

8:00 a.m.Welcome
Kadi Luchsinger, Guy Calvert

8:05 a.m.Introduction
Brenda Finucane     Themes and variations in dup15q

8:30 a.m.Epigenetic complexities at the heart of 15q11-13
Janine LaSalle        15q noncoding RNAs involved in topotecan action and diurnal metabolism  

9:10 a.m.BREAK

9:15 a.m.Discussion Panel: Sleep and Seizures in dup15q
Moderators: Brenda Finucane
Panelists: Janine LaSalle, Ron Thibert, Orrin Devinsky, Alessando di Rocco

10:05 a.m.     Keynote Speaker
Ben PhilpotPharmacogenetic insights into neurodevelopmental disorders

10:35 a.m.     BREAK

10:45 a.m.Fundamental Research: Part  1, Stem Cell Models
Moderators: Stormy Chamberlain & Larry Reiter
Joachim Hallmayer   Using iPS cells to understand neurodevelopmental disorders
Stormy ChamberlainInduced pluripotent stem cell models of dup15q: regulation of gene expression
and signaling pathways in human neurons
Larry ReiterDental pulp stem cells for the study of duplication 15q syndrome

12:00 p.m.      LUNCH
  Sandwiches catered at MIND

12:45 p.m.      Fundamental Research: Part 2, Flies, Mice and UBE3A
Moderators: Stormy Chamberlain & Janine LaSalle
Matt Anderson   New insight from the Ube3a Transgenic Mouse Model of Idic 15 Autism
Ugo Mayor Ube3a, the E3 ubiquitin ligase linked to dup15q autism, regulates protein
homeostasis through the proteasome
Larry ReiterIndentification of UBE3A targets that can influence the phenotypes in Angelman
syndrome and 15q duplication autism
Scott Dindot      Development and characterization of transgenic mouse models of dup15q

2:45 p.m.BREAK

3:00 p.m.      Fundamental Research: Part 3, Insights from Other Syndromes, Downstream Genes, & Pigs
Moderators: Janine LaSalle & Larry Reiter
Brett Abrahams An integrative approach towards the functional characterization of genetic variation
at 15q11.2 (BP1-BP2)
Reymundo Lozano    Lessons learned from the Clinical Trials of Fragile X Syndrome
Robert Nicholls  Prospects for porcine animal models for neurobehavioral disorders
Jamee Berg      JAKMIP1 is a Novel Component of an FMRP-Associated Translational
Complex and Regulates Neuronal Translation

4:50 p.m.       Conclude Day 1

6:00 p.m.Cocktail Reception
  Location TBD

Friday, September 20th

8:00 a.m.Discussion Panel: Next Steps for Fundamental and Translational Research
Moderators: Brenda Finucane & Janine LaSalle
Panelists: Larry Reiter, Stormy Chamberlain, Brett Abrahams, Matt Anderson, Ben Philpot, Scott Dindot

9:00 a.m.BREAK

9:10 a.m.Autism
Moderators: Larry Reiter & Sarah Spence
Christa Lese Martin  Defining copy number variants related to neurodevelopmental disorders
David SegalZFNs, TALENs and CRISPRs for ASD research (and treatment)
Ian King             Transcriptional effects of topoisomerase inhibitors on ASD candidate genes

Grant Belgard   Postmortem brain transcriptomics in chromosome 15q duplication syndrome
and idiopathic autism

11:00 a.m.BREAK

11:10 a.m.Discussion Panel: Characterizing and Treating Autism in Dup15q
Moderators: Brenda Finucane
Panelists: Shafali Jeste, Christa Lese Martin, Rob Ring, Dan Smith, John Spiro, Kathryn McVicar, Sarah Spence

12:00 p.m.      LUNCH
  Sandwiches catered at MIND

1:00 p.m.Epilepsy Case Studies and Data Management
Moderators: Ron Thibert & Orrin Devinsky
Orrin Devinsky   The Dup15q Database: How Far Can We Go?
Ron Thibert Clinical observations from Massachusetts General Hospital Clinic
Alessandro di RoccoParadoxical worsening of seizure activity with pregabalin in an adult with
isodicentric 15 syndrome involving duplications of the GABRB3, GABRA5
and GABRG3 genes

2:15 p.m.BREAK

2:30 p.m.Discussion Panel: Insights from Clinics and Registry
Moderators: Brenda Finucane & Sarah Spence
Panelists: Ron Thibert, Kathryn McVicar, Orrin Devinsky, Shafali Jeste, David Evans, Tee Viangteeravat,
Naga Nagisetty, Alessandro di Rocco, and Kadi Luchsinger

4:00 p.m.     Conclude Day 2

To register please fill out the form below by Friday, August 30th. Contact with any questions.

2013 Dup15q Scientific Meeting
I will be attending:
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Thursday, September 19thFriday, September 20thBoth days