Seizures

Seizures are common in individuals with dup15q syndrome. They can happen at any age, but are commonly begin at times of growth and change, such as infancy and puberty. There are many different types of seizures and the video below contains several examples.  This video should not be used as a diagnostic tool. If you believe your child has had a seizure, please consult your neurologist.

Types of seizures common in Dup15q Syndrome

Brief descriptions of the types of seizures shown in the video are below. Descriptions of absence seizures and simple partial seizures are also included.

Tonic-Clonic

Tonic-clonic seizures combine the characteristics of tonic and clonic seizures.  The tonic phase comes first: All the muscles stiffen and air being forced past the vocal cords may cause a cry or groan. The person loses consciousness and may fall to the floor. Next, the arms and legs begin to jerk rapidly and rhythmically, bending and relaxing at the elbows, hips, and knees. After a few minutes, the jerking slows and stops. Consciousness returns slowly, and the person may be drowsy, confused, agitated, or depressed. These seizures generally last 1 to 3 minutes. Tonic-clonic seizures were formally referred to as grand mal seizures.

Atonic

Muscle "tone" is the muscle's normal tension. Atonic means "without tone" so in an atonic seizure, muscles suddenly lose strength. The eyelids may droop, the head may nod, the person may drop things and may fall to the ground. These seizures are also called drop seizures. The person usually remains conscious. These seizures typically last less than 15 seconds. 

Myoclonic

Myoclonic seizures are brief, shock-like jerks of a muscle or a group of muscles. "Myo" means muscle and "clonus" means rapidly alternating contraction and relaxation—jerking or twitching—of a muscle. Usually they don't last more than a second or two. There can be just one, but sometimes many will occur within a short time. Myoclonic seizures usually cause abnormal movements on both sides of the body at the same time.

Tonic

In a tonic seizure, muscle tone is greatly increased and the body, arms, or legs make sudden stiffening movements. During the seizure, the person usually remains conscious. Tonic seizures most often occur during sleep and usually involve all or most of the brain, affecting both sides of the body. If the person is standing when the seizure starts, he or she may fall. These seizures usually last less than 20 seconds.

Absence

An absence seizure is characterized by a lapse of awareness, or staring into space. A simple absence seizure generally lasts less than 10 seconds. Because they happen so quickly, it’s very easy to miss them, or to confuse them with daydreaming or not paying attention. During a complex absence seizure, a person will make some kind of movement in addition to staring into space. Movements may include blinking, chewing, or hand gestures. A complex absence seizure can last up to 20 seconds.  Absence seizures were formally referred to as petit mal seizures.

Simple Partial

When people have simple partial seizures, they are fully awake, alert and able to interact throughout the seizure. There are several types of simple partial seizures.  In motor seizures, there is a change in muscle activity. For example, a person may have abnormal movements such as jerking of a finger or stiffening of part of the body. In sensory seizures, people may smell or taste things that aren't there; hear clicking, ringing, or a person's voice when there is no actual sound; or feel a sensation of "pins and needles" or numbness. They may have visual hallucinations or may experience illusions—distortions of true sensations. For instance, they may believe that a parked car is moving farther away, or that a person's voice is muffled when it's actually clear.  Autonomic seizures cause changes in the part of the nervous system that automatically controls bodily functions. These common seizures may include strange or unpleasant sensations in the stomach, chest, or head; changes in the heart rate or breathing; sweating; or goose bumps.  Psychic seizures change how people think, feel, or experience things. They may have problems with memory, garbled speech, an inability to find the right word, or trouble understanding spoken or written language. Or, they may suddenly feel emotions like fear, depression, or happiness with no outside reason.  Simple partial seizures are typically brief, lasting less than 2 minutes.

​Complex Partial

Complex partial seizures may start with a simple partial seizure as described above.  Then, the person loses awareness and stares blankly. Most people perform a repetitive action during the seizure, such as moving their mouth, picking at the air or their clothing. Less often, people may repeat words or phrases, laugh, scream, or cry.  Some display gross motor actions like bicycling movements of the legs or pelvic thrusting. Complex partial seizures usually last between 30 seconds and 2 minutes. Afterward, the person may be tired or confused for about 15 minutes and may not be return to normal function for hours.

Infantile Spasms

Infantile spasms are brief tonic seizures that begin presenting in children during the first 2 years of life. Some seizures are characterized by brief head nods, whereas others consist of violent flexion of the trunk, arms, and legs. Infantile spasms frequently occur in clusters, and the intensity and frequency of the spasms in each cluster may increase to a peak before progressively decreasing. The seizures are very brief, so casual observers may miss single seizures. The number of seizures per cluster varies considerably, with some clusters consisting of as many as 150 seizures. The number of clusters per day also varies, with some patients having as many as 60 clusters per day. Crying or irritability during or after a flurry of spasms is commonly observed.


Much of the information above is the intellectual property of the Epilepsy Foundation.  Copyright ©1996-2014 Epilepsy Foundation of America, Inc. Landover, MD. All rights reserved.  For more information about epilepsy and types of seizures, see www.epilepsy.com.