At the present time there is no specific treatment that can undo the genetic pattern seen in people affected by chromosome 15q duplications.  Although the fundamental genetic differences cannot be reversed, therapies are available to help address many of the symptoms associated with dup15q syndrome.  Physical, occupational, and speech therapy along with special education techniques can stimulate children with dup15q syndrome to develop to their full potential.

In terms of medical management of the symptoms associated with dup15q syndrome, families should be aware that individuals with chromosome 15 duplications may tolerate medications differently and may be more sensitive to side effects for some classes of medications, such as the selective serotonin reuptake inhibitors (SSRIs). These medications should be used with caution and any new medication should be instituted in a controlled setting, with slow titration up to the expected therapeutic dose, and with a clear idea of the expected outcome for the treatment. This includes supplements.