2017 Dup15q Alliance Scientific Symposium

Dup15q Alliance 2017 Science SYmposium

July 27 - 28, 2017
Luskin Conference Center

UCLA, Los Angeles, California

Symposium Agenda

Wednesday, July 26th

Time   Location

5pm

Symposium Registration Open

Laureate Classroom Foyer

5:30pm-7:30pm

Professional Advisory Board and Clinics Working Group Combined Meeting

Collaboration Boardroom

Thursday, July 27th

 

 

Presenter(s)

Discussant(s)

Panelists

6:30 am

Breakfast

Registration

Plateia B

Laureate Classrom Foyer

 

 

8:00 am

Welcoming remarks

Dr. Guy Calvert, PhD
Vanessa Vogel-Farley

 

 

8:10 am

Overview of the dup15q syndrome and a complex genomic region

Brenda Finucane, MS, LGC

 

 

8:40 am

Discussion Panel: Dup15q families tell their stories

The Poraths

The Calverts

The Seagars

The Greys

 

 

9:10am

Coffee Break

 

 

 

10:05am

Takumi Mouse Model of dup15q

Dr. Toru Takumi

 

 

10:45am

Modeling the efficacy of therapeutic approaches to normalize UBE3A dosage

Dr. Matthew Judson

 

 

11:10am

Mapping the Neuronal Circuits and Molecular Mechanisms in UBE3A Model of Dup15q

Dr. Matthew Anderson

 

 

11:40am

Neuronal overexpression of Ube3a isoform 2 causes behavioral impairments relevant to 15q11.2-q13.3 duplication syndrome

Dr. Jill Silverman

 

 

12pm

Examining Neuroanatomical Differences in Mouse Models of Neurodevelopmental Disorders using MRI - Focus on Dup15q

Dr. Jacob Ellegood

 

 

 

12:30pm

Discussion panel: Mouse models of dup15q

 

Dr. Ben Philpot

Dr. Stormy Chamberlain,             Dr. Matt Anderson,          Dr. Toru Takumi

1pm 

Lunch Break 

Plateia B

 

 

2:10 pm

Human stem cell models to study neuronal pathophysiology in chromosome 15q disorders

Dr. Eric Levine

 

 

2:40 pm

Glial overexpression of Dube3a causes seizures and synaptic impairments in Drosophila through down regulation of the Na+/K+ pump ATPα

Dr. Larry Reiter

 

 

3:10pm

Discussion panel: Biomarker investigations

 

Dr. Stormy Chamberlain

Dr. Larry Reiter, Dr. Eric Levine ,   Dr. Janine LaSalle, Dr. Carolyn Schanen

3:40pm

Coffee Break

 

 

 

3:55pm

Genome-wide changes to transcription, methylation, and histone variant H2A.Z following knockdown of UBE3A in Dup15q model

Dr. Janine LaSalle

 

 

4:25pm

Announcement of 2017-2018 Dup15q Fellowship Award Winner

Dr. Carolyn Schanen

 

 

4:35pm

End of Day 1 Presentations

 

 

 

 

Tour of UCLA research and clincal facilities

 

 

 

6:00 pm-7:30pm

Cocktail reception for meeting participants

Courtyard South

 

 

Friday, JULY 28TH

6:30 am

Breakfast

Registration

Plateia B

Laureate Classrom Foyer

 

 

8:00 am

A potential role of cannabidiol in the treatment of epilepsy

Dr. Shaun Hussain

 

 

8:30 am

Circadian function and dysfunction in autism: opportunities for interventions

Dr. Chris Colwell 

 

 

9:00 am Epilepsy and other clinical issues in Dup15q Dr. Raman Sankar    

9:20 am

Motor Function in Dup15q Syndrome

Dr. Rujuta Bhatt

 

 

9:45 am

Discussion Panel: Epilepsy and other clinical issues in Dup15q.

 

Dr. Raman Sankar

Dr. Sarah Spence,               Dr. Rujuta Bhatt,             Dr. Shafali Jeste, Dr. Carolyn Schanen

10:00am

Coffee Break

 

 

 

10:30am

Electrophysiological biomarkers in mouse models of Dup15q Syndrome

Dr. Peyman Golshani

 

 

11:00am

Understanding abilities in minimally verbal children: Considerations for behavioral assessments

Dr. Charlotte Di Stefano

 

 

11:30am

Understanding the brains of people with Dup15q

Dr. Alycia Halladay

 

 

11:45am

Functional genomics in (dup)15q11-13

Dr. Dan Geschwind

 

 

12:15pm

Lunch

 

 

 

1:15pm

Dup15q REDCap Research Databases

Oluwaseun Ajayi, MS

 

 

1:45 pm

Understanding mechanisms and clinical correlates underlying beta oscillations in Dup15q syndrome

Vidya Saravanapandian, MS

 

 

2:15pm

Discussion Panel: Evaluating Endpoints/Outcomes in dup15q syndrome

 

Dr. Shafali Jeste

Dr. Stormy Chamberlain, Dr. Dan Geschwind, Dr. Sarah Spence, Dr. Peyman Golshani

2:45pm

coffee break

 

 

 

3:15pm

“Allele-specific RNA interference to modulate gene expression of duplicated genes”

Dr. Alfredo Brusco

 

 

 

3:35pm

Modeling of prenatal infections to study the effects of maternal immune activation on fetal brain development and relevance to Autism Spectrum Disorder

Dr. Tiziano Pramparo

 

 

3:55pm

Hyperexcitability in stem cell-derived neurons from Dup15q patients

James Fink, BS, MS, Dup15q Alliance Fellow

   

4:25pm

Investigation of synergistic interactions among genes in the 15q11.2-q13.1 region using Drosophila melanogaster

Kevin Hope, BA, Dup15q Alliance Fellow

 

 

4:55pm

Closing Remarks

Dr. Guy Calvert, PhD

 

 

5:00pm

End of Research Meeting

     

Register Here

Registration Options:

Non-student, 2-meal/day option:

                                   Includes: 7/27- Breakfast, Lunch, Cocktail Reception                                                

                                                        7/28-  Breakfast and Lunch 

Non-student: 1-meal/day option:

                                 Includes: 7/27- Lunch, Cocktail Reception

                                                       7/28-  Lunch 

Student, 2-meal/day option: 

                             Includes: 7/27- Breakfast, Lunch, Cocktail Reception

                                                  7/28-  Breakfast and Lunch 

Student: 1-meal/day option:

                                 Includes: 7/27- Lunch, Cocktail Reception

                                                       7/28-  Lunch 

 If you have questions, please contact us at info@dup15q.org. Scientific meeting registration fees are non-refundable.

To pay via check or money order, send your payment made payable to "Dup15q Alliance" to P.O. Box 1669, Highland Park, IL 60035.

To become a Symposium sponsor, view our sponsorship form here.

 Travel awards supported by the Simons Foundation Autism Research Initiative (SFARI). 

Thank you to our sponsors!